8S3R

HUMAN PI3KDELTA IN COMPLEX WITH PYRIDAZINONE INHIBITOR 7

これはPDB形式変換不可エントリーです。

8S3R の概要

• エントリーDOI: 10.2210/pdb8s3r/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 5-[(1~{S})-1-[4-azanyl-3-(5-oxidanylpyridin-3-yl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-cyclopentyl-2-(phenylmethyl)pyridazin-3-one, ... (4 entities in total)
• 機能のキーワード: pi3kdelta kinase, pi3kdelta kinase inhibitor, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 137988.76

構造登録者

Pala, D.,Bruno, P.,Capelli, A.M.,Biagetti, M. (登録日: 2024-02-20, 公開日: 2024-07-03)

• 主引用文献: Bruno, P.,Micoli, A.,Corsi, M.,Pala, D.,Guariento, S.,Fiorelli, C.,Ronchi, P.,Fioni, A.,Gallo, P.M.,Marenghi, G.,Bertolini, S.,Capacchi, S.,Mileo, V.,Biagetti, M.,Capelli, A.M.; Discovery and Optimization of Pyridazinones as PI3K delta Selective Inhibitors for Administration by Inhalation.; J.Med.Chem., 2024; PubMed: 38907711; DOI: 10.1021/acs.jmedchem.4c00610

実験手法

X-RAY DIFFRACTION (2.28 Å)