8S16

c-KIT kinase domain in complex with imatinib

Summary for 8S16

• Entry DOI: 10.2210/pdb8s16/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: stem cell factor receptor, gist, kit, inhibitor, imatinib, resistance, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 75482.43

Authors

Teuber, A.,Mueller, M.P.,Rauh, D. (deposition date: 2024-02-15, release date: 2025-09-03)

• Primary citation: Teuber, A.,Niggenaber, J.,Kleinboelting, S.B.,Landel, I.,Warmuth, J.,Busick, D.,Bauer, S.,Rauh, D.; c-KIT kinase domain in complex with imatinib; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)