8S15

c-KIT kinase domain in complex with nintedanib

Summary for 8S15

• Entry DOI: 10.2210/pdb8s15/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, methyl (3Z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate (3 entities in total)
• Functional Keywords: stem cell factor receptor, gist, nintedanib, repurposing, inhibitor, cancer, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 37734.06

Authors

Teuber, A.,Kleinboelting, S.B.,Mueller, M.P.,Rauh, D. (deposition date: 2024-02-15, release date: 2025-09-03)

• Primary citation: Teuber, A.,Niggenaber, J.,Kleinboelting, S.B.,Landel, I.,Warmuth, J.,Busick, D.,Mueller, M.P.,Bauer, S.,Rauh, D.; c-KIT kinase domain in complex with nintedanib; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)