8S14

c-KIT kinase domain in complex with sunitinib

Summary for 8S14

• Entry DOI: 10.2210/pdb8s14/pdb
• Descriptor: Mast/stem cell growth factor receptor Kit, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: stem cell factor receptor, inhibitor, gist, sunitinib, cancer, resistance, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 37752.49

Authors

Teuber, A.,Niggenaber, J.,Landel, I.,Mueller, M.P.,Rauh, D. (deposition date: 2024-02-15, release date: 2025-09-03)

• Primary citation: Teuber, A.,Niggenaber, J.,Kleinboelting, S.B.,Landel, I.,Warmuth, J.,Busick, D.,Mueller, M.P.,Bauer, S.,Rauh, D.; c-KIT kinase domain in complex with sunitinib; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)