8RVH

Structure of the binding domain of BoNT/A mutant Y1117V/H1253K in complex with the GD1a ganglioside receptor

Summary for 8RVH

• Entry DOI: 10.2210/pdb8rvh/pdb
• Descriptor: Botulinum neurotoxin A heavy chain, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid, ... (4 entities in total)
• Functional Keywords: botulinum neurotoxin, receptor binding, ganglioside, toxin
• Biological source: Clostridium botulinum
• Total number of polymer chains: 1
• Total formula weight: 52966.56

Authors

Masuyer, G.,Stenmark, P. (deposition date: 2024-02-01, release date: 2025-02-12)

• Primary citation: Masuyer, G.,Rummel, A.,Stenmark, P.; Characterisation of botulinum neurotoxin A mutants with enhanced ganglioside binding properties yielding improved potency; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)