8RH1

Trimeric HSV-2F gB ectodomain in postfusion conformation with three bound HDIT101 Fab molecules.

Summary for 8RH1

Entry DOI	10.2210/pdb8rh1/pdb
EMDB information	19163 19164 19165 19166
Descriptor	Envelope glycoprotein B, HDIT101 Fab heavy chain, HDIT101 Fab light chain (3 entities in total)
Functional Keywords	ectodomain, post-fusion, fab molecule, trimeric, viral protein
Biological source	Human herpesvirus 2 strain G More
Total number of polymer chains	9
Total formula weight	458997.39
Authors	Kalbermatter, D.,Seyfizadeh, N.,Imhof, T.,Ries, M.,Mueller, C.,Jenner, L.,Blumenschein, E.,Yendrzheyevskiy, A.,Moog, K.,Eckert, D.,Engel, R.,Diebolder, P.,Chami, M.,Krauss, J.,Schaller, T.,Arndt, M. (deposition date: 2023-12-14, release date: 2024-06-19)
Primary citation	Seyfizadeh, N.,Kalbermatter, D.,Imhof, T.,Ries, M.,Muller, C.,Jenner, L.,Blumenschein, E.,Yendrzheyevskiy, A.,Grun, F.,Moog, K.,Eckert, D.,Engel, R.,Diebolder, P.,Chami, M.,Krauss, J.,Schaller, T.,Arndt, M. Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus. J.Biomed.Sci., 31:56-56, 2024 Cited by PubMed: 38807208 DOI: 10.1186/s12929-024-01045-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.45 Å)

Structure validation