8RDQ

Cereblon isoform 4 from Magnetospirillum gryphiswaldense in complex with spiro-isoxazol based compound 8b

8RDQ の概要

• エントリーDOI: 10.2210/pdb8rdq/pdb
• 分子名称: Cereblon isoform 4, ZINC ION, (5S)-3-(2,4-dichlorophenyl)-1-oxa-2,9-diazaspiro[4.5]dec-2-ene-8,10-dione, ... (5 entities in total)
• 機能のキーワード: cereblon, ubiquitination, e3, molecular glue, spiro-isoxazole, signaling protein
• 由来する生物種: Magnetospirillum gryphiswaldense
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 42028.20

構造登録者

Bischof, L.,Hartmann, M.D. (登録日: 2023-12-08, 公開日: 2024-04-10)

• 主引用文献: Shevalev, R.,Bischof, L.,Sapegin, A.,Bunev, A.,Olga, G.,Kantin, G.,Kalinin, S.,Hartmann, M.D.; Discovery and characterization of potent spiro-isoxazole-based cereblon ligands with a novel binding mode.; Eur.J.Med.Chem., 270:116328-116328, 2024; PubMed: 38552426; DOI: 10.1016/j.ejmech.2024.116328

実験手法

X-RAY DIFFRACTION (2.03 Å)