8RDK

Crystal structure of human Haspin (GSG2) kinase bound to MD420

Summary for 8RDK

• Entry DOI: 10.2210/pdb8rdk/pdb
• Descriptor: Serine/threonine-protein kinase haspin, ZINC ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
• Functional Keywords: haspin, kinase, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41140.35

Authors

Kraemer, A.,Defois, M.,Giraud, F.,Moreau, P.,Anizon, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-12-08, release date: 2024-03-06, Last modification date: 2024-08-07)

• Primary citation: Greco, F.A.,Kramer, A.,Wahl, L.,Elson, L.,Ehret, T.A.L.,Gerninghaus, J.,Mockel, J.,Muller, S.,Hanke, T.,Knapp, S.; Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting.; Eur.J.Med.Chem., 276:116672-116672, 2024; PubMed: 39067440; DOI: 10.1016/j.ejmech.2024.116672

Experimental method

X-RAY DIFFRACTION (2 Å)