8RDK
Crystal structure of human Haspin (GSG2) kinase bound to MD420
Summary for 8RDK
Entry DOI | 10.2210/pdb8rdk/pdb |
Descriptor | Serine/threonine-protein kinase haspin, ZINC ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total) |
Functional Keywords | haspin, kinase, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41140.35 |
Authors | Kraemer, A.,Defois, M.,Giraud, F.,Moreau, P.,Anizon, F.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-12-08, release date: 2024-03-06, Last modification date: 2024-08-07) |
Primary citation | Greco, F.A.,Kramer, A.,Wahl, L.,Elson, L.,Ehret, T.A.L.,Gerninghaus, J.,Mockel, J.,Muller, S.,Hanke, T.,Knapp, S. Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276:116672-116672, 2024 Cited by PubMed: 39067440DOI: 10.1016/j.ejmech.2024.116672 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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