8RB6
Structure of Aldo-Keto Reductase 1C3 (AKR1C3) in complex with an inhibitor M689, with the 3-hydroxy-benzoisoxazole moiety. Resolution 2.0A
Summary for 8RB6
Entry DOI | 10.2210/pdb8rb6/pdb |
Descriptor | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[[4-(3-hydroxyphenyl)phenyl]amino]-1,2-benzoxazol-3-ol, ... (5 entities in total) |
Functional Keywords | aldo-keto reductase, akr1c3, inhibitor, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 76060.06 |
Authors | |
Primary citation | Pippione, A.C.,Kovachka, S.,Vigato, C.,Bertarini, L.,Mannella, I.,Sainas, S.,Rolando, B.,Denasio, E.,Piercy-Mycock, H.,Romalho, L.,Salladini, E.,Adinolfi, S.,Zonari, D.,Peraldo-Neia, C.,Chiorino, G.,Passoni, A.,Mirza, O.A.,Frydenvang, K.,Pors, K.,Lolli, M.L.,Spyrakis, F.,Oliaro-Bosso, S.,Boschi, D. Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer. Eur.J.Med.Chem., 268:116193-116193, 2024 Cited by PubMed: 38364714DOI: 10.1016/j.ejmech.2024.116193 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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