8R9O

A soakable crystal form of human CDK7 in complex with AMP-PNP

Summary for 8R9O

Entry DOI	10.2210/pdb8r9o/pdb
Descriptor	Cyclin-dependent kinase 7, ~{N}-[(1~{S})-2-(dimethylamino)-1-phenyl-ethyl]-6,6-dimethyl-3-[[4-(propanoylamino)phenyl]carbonylamino]-1,4-dihydropyrrolo[3,4-c]pyrazole-5-carboxamide (3 entities in total)
Functional Keywords	serine-threonine kinase, phosphorylation, cell cycle progression, atp binding, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	85506.52
Authors	Mukherjee, M.,Cleasby, A. (deposition date: 2023-11-30, release date: 2024-05-29, Last modification date: 2024-06-26)
Primary citation	Mukherjee, M.,Day, P.J.,Laverty, D.,Bueren-Calabuig, J.A.,Woodhead, A.J.,Griffiths-Jones, C.,Hiscock, S.,East, C.,Boyd, S.,O'Reilly, M. Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design. Structure, 2024 Cited by PubMed: 38870939 DOI: 10.1016/j.str.2024.05.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation