8R6N

Crystal structure of Candida glabrata Bdf1 bromodomain 2 bound to a pyridoindole ligand

Summary for 8R6N

• Entry DOI: 10.2210/pdb8r6n/pdb
• Descriptor: Candida glabrata strain CBS138 chromosome C complete sequence, 2-ethanoyl-~{N}-(4-morpholin-4-ylphenyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole-8-carboxamide (3 entities in total)
• Functional Keywords: bromodomain, transcription
• Biological source: Nakaseomyces glabratus
• Total number of polymer chains: 1
• Total formula weight: 14192.10

Authors

Petosa, C.,Wei, K.,McKenna, C.E.,Govin, J. (deposition date: 2023-11-22, release date: 2024-10-30)

• Primary citation: Wei, K.,Arlotto, M.,Overhulse, J.M.,Dinh, T.A.,Zhou, Y.,Dupper, N.J.,Yang, J.,Kashemirov, B.A.,Dawi, H.,Garnaud, C.,Bourgine, G.,Mietton, F.,Champleboux, M.,Larabi, A.,Hayat, Y.,Indorato, R.L.,Noirclerc-Savoye, M.,Skoufias, D.,Cornet, M.,Rabut, G.,McKenna, C.E.,Petosa, C.,Govin, J.; Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors with Antifungal Potential against invasive Candida infection; Advanced Science, 2024

Experimental method

X-RAY DIFFRACTION (2.11 Å)