8R19

SARS-CoV-2 Mpro (Omicron, P132H) free enzyme

8R19 の概要

• エントリーDOI: 10.2210/pdb8r19/pdb
• 分子名称: 3C-like proteinase nsp5 (2 entities in total)
• 機能のキーワード: sars-cov-2; main protease; omicron; molecular dynamics; pro>his mutant; double mutant, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33866.58

構造登録者

Ibrahim, M.,Sun, X.,Hilgenfeld, R. (登録日: 2023-11-01, 公開日: 2023-11-29, 最終更新日: 2025-04-09)

• 主引用文献: Ibrahim, M.,Sun, X.,Martins de Oliveira, V.,Liu, R.,Clayton, J.,El Kilani, H.,Shen, J.,Hilgenfeld, R.; Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart? A crystallographic, biophysical, and theoretical study; Hlife, 2:419-433, 2024; DOI: 10.1016/j.hlife.2024.06.003

実験手法

X-RAY DIFFRACTION (1.91 Å)