8R03

Staphylococcus aureus ClpP in complex with the natural product beta-lactone inhibitor Cystargolide A at 2.0 A resolution

8R03 の概要

• エントリーDOI: 10.2210/pdb8r03/pdb
• 関連するPDBエントリー: 3V5E
• 分子名称: ATP-dependent Clp protease proteolytic subunit, Cystargolide A (bound), 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: anti-virulence, caseinolytic protease, inhibitor, natural product, mode of action, hydrolase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 307713.78

構造登録者

Illigmann, A.,Vielberg, M.-T.,Lakemeyer, M.,Wolf, F.,Staudt, N.,Dema, T.,Stange, P.,Liebhart, E.,Kuttenlochner, W.,Kulik, A.,Malik, I.,Grond, S.,Sieber, S.A.,Groll, M.,Kaysser, L.,Broetz-Oesterhelt, H. (登録日: 2023-10-30, 公開日: 2023-12-20, 最終更新日: 2024-01-24)

• 主引用文献: Illigmann, A.,Vielberg, M.T.,Lakemeyer, M.,Wolf, F.,Dema, T.,Stange, P.,Kuttenlochner, W.,Liebhart, E.,Kulik, A.,Staudt, N.D.,Malik, I.,Grond, S.,Sieber, S.A.,Kaysser, L.,Groll, M.,Brotz-Oesterhelt, H.; Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A.; Angew.Chem.Int.Ed.Engl., 63:e202314028-e202314028, 2024; PubMed: 38029352; DOI: 10.1002/anie.202314028

実験手法

X-RAY DIFFRACTION (2 Å)