8QWA

Adenylosuccinate Synthetase from H. pylori in complex with PLP and IMP

Summary for 8QWA

• Entry DOI: 10.2210/pdb8qwa/pdb
• Descriptor: Adenylosuccinate synthetase, INOSINIC ACID, PYRIDOXAL-5'-PHOSPHATE, ... (6 entities in total)
• Functional Keywords: purine salvage pathway, complex with inhibitor, amp precursos synthesis, ligase
• Biological source: Helicobacter pylori 26695
• Total number of polymer chains: 1
• Total formula weight: 46593.20

Authors

Bzowska, A.,Narczyk, M.,Maksymiuk, W. (deposition date: 2023-10-19, release date: 2024-09-04)

• Primary citation: Wojtys, M.I.,Maksymiuk, W.,Narczyk, M.,Bubic, A.,Asler, I.L.,Krzyzek, P.,Gosciniak, G.,Jagusztyn-Krynicka, E.K.,Bzowska, A.; Vitamin B6 inhibits activity of Helicobacter pylori adenylosuccinate synthetase and growth of reference and clinical, antibiotic-resistant H. pylori strains.; J Enzyme Inhib Med Chem, 39:2372734-2372734, 2024; PubMed: 39149761; DOI: 10.1080/14756366.2024.2372734

Experimental method

X-RAY DIFFRACTION (1.85 Å)