8QU9

Structure of the NCOA4 (Nuclear Receptor Coactivator 4)-FTH1 (H-Ferritin) complex

Summary for 8QU9

• Entry DOI: 10.2210/pdb8qu9/pdb
• EMDB information: 18658
• Descriptor: Ferritin heavy chain, NCOA4 (Nuclear Receptor Coactivator 4), FE (III) ION, ... (4 entities in total)
• Functional Keywords: ferritinophagy, iron homeostasis, ncoa4, ferritin heavy chain, metal transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 22752.91

Authors

Hoelzgen, F.,Klukin, E.,Zalk, R.,Shahar, A.,Cohen-Schwartz, S.,Frank, G.A. (deposition date: 2023-10-15, release date: 2024-05-15)

• Primary citation: Hoelzgen, F.,Nguyen, T.T.P.,Klukin, E.,Boumaiza, M.,Srivastava, A.K.,Kim, E.Y.,Zalk, R.,Shahar, A.,Cohen-Schwartz, S.,Meyron-Holtz, E.G.,Bou-Abdallah, F.,Mancias, J.D.,Frank, G.A.; Structural basis for the intracellular regulation of ferritin degradation.; Nat Commun, 15:3802-3802, 2024; PubMed: 38714719; DOI: 10.1038/s41467-024-48151-1

Experimental method

ELECTRON MICROSCOPY (2.88 Å)