8QTL

Aplysia californica acetylcholine-binding protein in complex with Spiroimine (-)-4 S

Summary for 8QTL

• Entry DOI: 10.2210/pdb8qtl/pdb
• Related: 8Q1M
• Descriptor: Soluble acetylcholine receptor, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spiroimine (-)-4 S, ... (6 entities in total)
• Functional Keywords: achbp, complex, spiroimine, aplysia californica, choline-binding protein
• Biological source: Aplysia californica (California sea hare)
• Total number of polymer chains: 5
• Total formula weight: 125775.47

Authors

Sulzenbacher, G.,Bourne, Y.,Marchot, P. (deposition date: 2023-10-12, release date: 2024-04-03, Last modification date: 2024-05-08)

• Primary citation: Bourne, Y.,Sulzenbacher, G.,Chabaud, L.,Araoz, R.,Radic, Z.,Conrod, S.,Taylor, P.,Guillou, C.,Molgo, J.,Marchot, P.; The Cyclic Imine Core Common to the Marine Macrocyclic Toxins Is Sufficient to Dictate Nicotinic Acetylcholine Receptor Antagonism.; Mar Drugs, 22:-, 2024; PubMed: 38667766; DOI: 10.3390/md22040149

Experimental method

X-RAY DIFFRACTION (1.85 Å)