8QQ4
LTA4 hydrolase in complex with compound 6(R)
Summary for 8QQ4
Entry DOI | 10.2210/pdb8qq4/pdb |
Descriptor | Leukotriene A-4 hydrolase, ZINC ION, ACETATE ION, ... (7 entities in total) |
Functional Keywords | lta4h, inhibitors, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 70590.50 |
Authors | Srinivas, H. (deposition date: 2023-10-03, release date: 2023-12-06, Last modification date: 2023-12-27) |
Primary citation | Thoma, G.,Markert, C.,Lueoend, R.,Miltz, W.,Spanka, C.,Bollbuck, B.,Wolf, R.M.,Srinivas, H.,Penno, C.A.,Kiffe, M.,Gajewska, M.,Bednarczyk, D.,Wieczorek, G.,Evans, A.,Beerli, C.,Rohn, T.A. Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase. J.Med.Chem., 66:16410-16425, 2023 Cited by PubMed: 38015154DOI: 10.1021/acs.jmedchem.3c01866 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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