8QLQ
Human MST3 (STK24) kinase in complex with macrocyclic inhibitor JA310
Summary for 8QLQ
Entry DOI | 10.2210/pdb8qlq/pdb |
Descriptor | Serine/threonine-protein kinase 24, macrocyclic inhibitor, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | selective kinase inhibitors, macrocyclic inhibitors, structure-guided drug design, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34959.10 |
Authors | Balourdas, D.I.,Amrhein, J.A.,Hanke, T.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-09-20, release date: 2023-11-08, Last modification date: 2024-05-29) |
Primary citation | Amrhein, J.A.,Berger, L.M.,Balourdas, D.I.,Joerger, A.C.,Menge, A.,Kramer, A.,Frischkorn, J.M.,Berger, B.T.,Elson, L.,Kaiser, A.,Schubert-Zsilavecz, M.,Muller, S.,Knapp, S.,Hanke, T. Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. J.Med.Chem., 67:674-690, 2024 Cited by PubMed: 38126712DOI: 10.1021/acs.jmedchem.3c01980 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.64 Å) |
Structure validation
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