8QLQ

Human MST3 (STK24) kinase in complex with macrocyclic inhibitor JA310

Summary for 8QLQ

Entry DOI	10.2210/pdb8qlq/pdb
Descriptor	Serine/threonine-protein kinase 24, macrocyclic inhibitor, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	selective kinase inhibitors, macrocyclic inhibitors, structure-guided drug design, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34959.10
Authors	Balourdas, D.I.,Amrhein, J.A.,Hanke, T.,Knapp, S.,Joerger, A.C.,Structural Genomics Consortium (SGC) (deposition date: 2023-09-20, release date: 2023-11-08, Last modification date: 2024-05-29)
Primary citation	Amrhein, J.A.,Berger, L.M.,Balourdas, D.I.,Joerger, A.C.,Menge, A.,Kramer, A.,Frischkorn, J.M.,Berger, B.T.,Elson, L.,Kaiser, A.,Schubert-Zsilavecz, M.,Muller, S.,Knapp, S.,Hanke, T. Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. J.Med.Chem., 67:674-690, 2024 Cited by PubMed: 38126712 DOI: 10.1021/acs.jmedchem.3c01980 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.64 Å)

Structure validation