8QER

Pseudomonas aeruginosa FabF C164A in complex with 4-(1H-pyrazole-3-carbonylamino)pentanoic acid

Summary for 8QER

• Entry DOI: 10.2210/pdb8qer/pdb
• Related: 8PD1 8PFZ
• Descriptor: 3-oxoacyl-[acyl-carrier-protein] synthase 2, (4~{R})-4-(1~{H}-pyrazol-3-ylcarbonylamino)pentanoic acid, FORMIC ACID, ... (7 entities in total)
• Functional Keywords: inhibitor, protein-ligand complex, fabf, transferase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 89470.22

Authors

Yadrykhins'ky, V.,Brenk, R.,Georgiou, C. (deposition date: 2023-09-01, release date: 2024-01-10, Last modification date: 2024-01-17)

• Primary citation: Georgiou, C.,Espeland, L.O.,Bukya, H.,Yadrykhinsky, V.,Haug, B.E.,Mainkar, P.,Brenk, R.; New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion; Chemrxiv, 2023; DOI: 10.26434/chemrxiv-2023-cwk25

Experimental method

X-RAY DIFFRACTION (1.95 Å)