8QAZ
Crystal Structure of BRPF1 bromodomain in complex with acetyl-pyrrole derivative compound 3
Summary for 8QAZ
Entry DOI | 10.2210/pdb8qaz/pdb |
Descriptor | Peregrin, 2-[4-[4-ethanoyl-5-methyl-3-(3-methylbutyl)-1~{H}-pyrrol-2-yl]-1,3-thiazol-2-yl]guanidine, NITRATE ION, ... (4 entities in total) |
Functional Keywords | four helical bundle, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 14099.15 |
Authors | |
Primary citation | Cazzanelli, G.,Dalle Vedove, A.,Caflisch, A.,Lolli, G. Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines To be published, |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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