8QAL
Crystal Structure of the first bromodomain of BRD4 in complex with acetyl-pyrrole derivative compound 83
Summary for 8QAL
Entry DOI | 10.2210/pdb8qal/pdb |
Related | 7QZ0 |
Descriptor | Bromodomain-containing protein 4, 2-[4-(3-methyl-4-oxidanylidene-2,5,6,7-tetrahydroisoindol-1-yl)-1,3-thiazol-2-yl]guanidine, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | four helical bundle, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15574.94 |
Authors | |
Primary citation | Cazzanelli, G.,Dalle Vedove, A.,Caflisch, A.,Lolli, G. Dual BET/BRPF1 inhibitors induce morphological alteration and cellular death in various human cancer cell lines To be published, |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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