8Q8N

Crystal structure of human GPX4-U46C-I129S-L130S

Summary for 8Q8N

• Entry DOI: 10.2210/pdb8q8n/pdb
• Related: 8Q8J
• Descriptor: Phospholipid hydroperoxide glutathione peroxidase (2 entities in total)
• Functional Keywords: redox, ferroptosis, gpx4, membrane associated, metabolism, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 19582.49

Authors

Bostock, M.J.,Mourao, A.,Napolitano, V.,Sattler, M.,Conrad, M.,Popowicz, G. (deposition date: 2023-08-18, release date: 2024-08-28)

• Primary citation: Lorenz, S.M.,Wahida, A.,Elmer, D.,Bostock, M.J.,Seibt, T.,Mourao, A.,Trumbach, D.,Rizzollo, F.,Napolitano, V.,Kolonko-Adamska, M.,Sommer, J.,Woo, M.S.,Rothammer, N.,Gaussman, S.,Alves, F.,Burkle, E.,Wanninger, J.,Boxleitner, K.M.,Stadler, M.,Doll, S.,Mishima, E.,Nakamura, T.,Maida, A.,Hass, D.,Escamilla-Ayala, A.,Puentes, L.P.,Lenberg, J.,Friedman, J.,Scale, C.,Proneth, B.,Henkelmann, B.,Aldrovandi, M.,Agostinis, P.,Zimprich, A.,Vogt-Weisenhorn, D.,Holter-Koch, S.,Lewerenz, J.,Steinacker, P.,Garcia-Saez, A.J.,Wurst, W.,Tietze, A.,Mann, M.,Westmeyer, G.G.,Friese, M.A.,Ramesh, S.K.,Wigby, K.,Sattler, M.,Ingold, I.,Ayton, S.,Jayavelu, A.K.,Popowicz, G.,Conrad, M.; An ultra-rare variant of GPX4 reveals the structural basis to avert neurodegeneration; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)