8Q77

STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA'; CSNK2A2 GENE PRODUCT) IN COMPLEX WITH THE BISUBSTRATE INHIBITOR ARC-780

Summary for 8Q77

• Entry DOI: 10.2210/pdb8q77/pdb
• Descriptor: Casein kinase II subunit alpha', (2~{S})-2-[[(2~{S})-2-[[(2~{S})-2-[12-[[4-[[5-(4-carboxyphenyl)-1,3-thiazol-2-yl]amino]-4-oxidanylidene-butanoyl]-(2-hydroxy-2-oxoethyl)amino]dodecanoylamino]-4-oxidanyl-4-oxidanylidene-butanoyl]amino]-4-oxidanyl-4-oxidanylidene-butanoyl]amino]butanedioic acid, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: protein kinase ck2 casein kinase 2 bisubstrate inhibitor n-terminal segment ligand binding site, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 45129.60

Authors

Werner, C.,Lindenblatt, D.,Niefind, K. (deposition date: 2023-08-15, release date: 2023-12-06)

• Primary citation: Werner, C.,Lindenblatt, D.,Viht, K.,Uri, A.,Niefind, K.; Discovery and Exploration of Protein Kinase CK2 Binding Sites Using CK2alpha Cys336Ser as an Exquisite Crystallographic Tool; Kinases Phosphatases, 2023; DOI: 10.3390/kinasesphosphatases1040018

Experimental method

X-RAY DIFFRACTION (1.255 Å)