8Q3U

Crystal structure of a fentanyl derivative in complex with human CA VII

8Q3U の概要

• エントリーDOI: 10.2210/pdb8q3u/pdb
• 分子名称: Carbonic anhydrase 7, ZINC ION, ~{N}-phenyl-~{N}-[1-[2-(4-sulfamoylphenyl)ethyl]piperidin-4-yl]propanamide, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, fentanyl derivative, metalloenzyme, complex, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31590.84

構造登録者

Alterio, V.,Di Fiore, A.,De Simone, G. (登録日: 2023-08-04, 公開日: 2023-09-20)

• 主引用文献: Angeli, A.,Micheli, L.,Turnaturi, R.,Pasquinucci, L.,Parenti, C.,Alterio, V.,Di Fiore, A.,De Simone, G.,Monti, S.M.,Carta, F.,Di Cesare Mannelli, L.,Ghelardini, C.,Supuran, C.T.; Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for mu Opioid receptor for Safer and long-lasting analgesia.; Eur.J.Med.Chem., 260:115783-115783, 2023; PubMed: 37678143; DOI: 10.1016/j.ejmech.2023.115783

実験手法

X-RAY DIFFRACTION (1.1 Å)