8Q1J
LSD1 Y391K-CoREST bound to Acetylated K14 of Histone H3
Summary for 8Q1J
Entry DOI | 10.2210/pdb8q1j/pdb |
Descriptor | Lysine-specific histone demethylase 1A, REST corepressor 1, Histone H3.3C, ... (4 entities in total) |
Functional Keywords | histone code, demethylase, flavin, oxidoreductase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 104580.51 |
Authors | Barone, M.,Mattevi, A. (deposition date: 2023-07-31, release date: 2024-05-15, Last modification date: 2024-07-17) |
Primary citation | Lee, K.,Barone, M.,Waterbury, A.L.,Jiang, H.,Nam, E.,DuBois-Coyne, S.E.,Whedon, S.D.,Wang, Z.A.,Caroli, J.,Neal, K.,Ibeabuchi, B.,Dhoondia, Z.,Kuroda, M.I.,Liau, B.B.,Beck, S.,Mattevi, A.,Cole, P.A. Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1. Nat.Chem.Biol., 2024 Cited by PubMed: 38965385DOI: 10.1038/s41589-024-01671-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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