8Q1J

LSD1 Y391K-CoREST bound to Acetylated K14 of Histone H3

Summary for 8Q1J

• Entry DOI: 10.2210/pdb8q1j/pdb
• Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, Histone H3.3C, ... (4 entities in total)
• Functional Keywords: histone code, demethylase, flavin, oxidoreductase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 104580.51

Authors

Barone, M.,Mattevi, A. (deposition date: 2023-07-31, release date: 2024-05-15, Last modification date: 2024-07-17)

• Primary citation: Lee, K.,Barone, M.,Waterbury, A.L.,Jiang, H.,Nam, E.,DuBois-Coyne, S.E.,Whedon, S.D.,Wang, Z.A.,Caroli, J.,Neal, K.,Ibeabuchi, B.,Dhoondia, Z.,Kuroda, M.I.,Liau, B.B.,Beck, S.,Mattevi, A.,Cole, P.A.; Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1.; Nat.Chem.Biol., 2024; PubMed: 38965385; DOI: 10.1038/s41589-024-01671-9

Experimental method

X-RAY DIFFRACTION (2.87 Å)