8PZB

crystal structure of VDR in complex with D-Bishomo-1a,25-dihydroxyvitamin D3 Analog 49

8PZB の概要

• エントリーDOI: 10.2210/pdb8pzb/pdb
• 分子名称: Vitamin D3 receptor A, Nuclear receptor coactivator 2, (1~{R},3~{S},5~{Z})-5-[(2~{E})-2-[(4~{a}~{R},5~{S},9~{a}~{S})-4~{a}-methyl-5-[(2~{R})-6-methyl-6-oxidanyl-heptan-2-yl]-3,4,5,6,7,8,9,9~{a}-octahydro-2~{H}-benzo[7]annulen-1-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, vdr, agonist, transcription
• 由来する生物種: Danio rerio (zebrafish); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36085.23

構造登録者

Rochel, N. (登録日: 2023-07-27, 公開日: 2024-04-24, 最終更新日: 2024-05-22)

• 主引用文献: Fabisiak, A.,Brzeminski, P.,Sicinski, R.R.,Rochel, N.,Maj, E.,Filip-Psurska, B.,Wietrzyk, J.,Plum, L.A.,DeLuca, H.F.; Design, synthesis, and biological activity of D-bishomo-1 alpha ,25-dihydroxyvitamin D 3 analogs and their crystal structures with the vitamin D nuclear receptor.; Eur.J.Med.Chem., 271:116403-116403, 2024; PubMed: 38615411; DOI: 10.1016/j.ejmech.2024.116403

実験手法

X-RAY DIFFRACTION (2.73 Å)