8PXM

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (1R,1'R)-7,7'-(pentane-1,5-diylbis(oxy))bis(1,3-dimethyl-1,3-dihydro-2H-benzo[d]azepin-2-one)

8PXM の概要

• エントリーDOI: 10.2210/pdb8pxm/pdb
• 分子名称: Bromodomain-containing protein 4, (1R)-7-[5-[[(1R)-1,3-dimethyl-2-oxidanylidene-1H-3-benzazepin-7-yl]oxy]pentoxy]-1,3-dimethyl-1H-3-benzazepin-2-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30735.42

構造登録者

Chung, C.W. (登録日: 2023-07-23, 公開日: 2023-10-04)

• 主引用文献: Bamborough, P.,Chung, C.W.,Goodwin, N.C.,Mitchell, D.J.,Neipp, C.E.,Phillipou, A.,Preston, A.,Prinjha, R.K.,Soden, P.E.,Watson, R.J.,Demont, E.H.; Design and Characterization of 1,3-Dihydro-2 H -benzo[ d ]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors.; Acs Med.Chem.Lett., 14:1231-1236, 2023; PubMed: 37736196; DOI: 10.1021/acsmedchemlett.3c00242

実験手法

X-RAY DIFFRACTION (2.378 Å)