8PWK
human HINT1 in complex with compound AT8003
Summary for 8PWK
Entry DOI | 10.2210/pdb8pwk/pdb |
Descriptor | Histidine triad nucleotide-binding protein 1, [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate, SODIUM ION, ... (4 entities in total) |
Functional Keywords | complex intermediate compound inhibitor, adenosine 5'-monophosphoramidase, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 28063.13 |
Authors | Zimberger, C.,Canard, B.,Ferron, F. (deposition date: 2023-07-20, release date: 2024-07-31, Last modification date: 2024-09-04) |
Primary citation | Chazot, A.,Zimberger, C.,Feracci, M.,Moussa, A.,Good, S.,Sommadossi, J.P.,Alvarez, K.,Ferron, F.,Canard, B. The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution. Plos Biol., 22:e3002743-e3002743, 2024 Cited by PubMed: 39190717DOI: 10.1371/journal.pbio.3002743 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.095 Å) |
Structure validation
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