8PWK

human HINT1 in complex with compound AT8003

8PWK の概要

• エントリーDOI: 10.2210/pdb8pwk/pdb
• 分子名称: Histidine triad nucleotide-binding protein 1, [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: complex intermediate compound inhibitor, adenosine 5'-monophosphoramidase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28063.13

構造登録者

Zimberger, C.,Canard, B.,Ferron, F. (登録日: 2023-07-20, 公開日: 2024-07-31, 最終更新日: 2024-09-04)

• 主引用文献: Chazot, A.,Zimberger, C.,Feracci, M.,Moussa, A.,Good, S.,Sommadossi, J.P.,Alvarez, K.,Ferron, F.,Canard, B.; The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution.; Plos Biol., 22:e3002743-e3002743, 2024; PubMed: 39190717; DOI: 10.1371/journal.pbio.3002743

実験手法

X-RAY DIFFRACTION (2.095 Å)