8PVP

Crystal structure of human Casein Kinase II subunit alpha (CK2a1) in complex with allosteric compound FGJG18

Summary for 8PVP

Entry DOI	10.2210/pdb8pvp/pdb
Descriptor	Casein kinase II subunit alpha, ~{N}-[5-[(3-chloranyl-4-phenyl-phenyl)methylamino]pentyl]isoquinoline-5-sulfonamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	kinase, ck2, allosteric inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	82892.87
Authors	Kraemer, A.,Greco, F.,Gerninghaus, J.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-07-18, release date: 2023-09-20, Last modification date: 2024-08-07)
Primary citation	Greco, F.A.,Kramer, A.,Wahl, L.,Elson, L.,Ehret, T.A.L.,Gerninghaus, J.,Mockel, J.,Muller, S.,Hanke, T.,Knapp, S. Synthesis and evaluation of chemical linchpins for highly selective CK2 alpha targeting. Eur.J.Med.Chem., 276:116672-116672, 2024 Cited by PubMed: 39067440 DOI: 10.1016/j.ejmech.2024.116672 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation