8PTA
JNK1 covalently bound to BD837 cyclohexenone based inhibitor
Summary for 8PTA
Entry DOI | 10.2210/pdb8pta/pdb |
Descriptor | Mitogen-activated protein kinase 8, methyl (1R,3S)-1-methyl-3-[[3-[[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]carbamoyl]-4-oxidanylidene-cyclohexane-1-carboxylate, GLYCEROL, ... (4 entities in total) |
Functional Keywords | mapk kinase, mapk, inhibitor, covalent, jnk, signaling protein, michael acceptor warhead |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 127967.72 |
Authors | |
Primary citation | Sok, P.,Poti, A.,Balint, D.,Remenyi, A.,Soos, T. Tunable c-Jun N-terminal kinase (JNK) inhibitors that target a specific cysteine by a reversible covalent bond To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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