8PTA

JNK1 covalently bound to BD837 cyclohexenone based inhibitor

8PTA の概要

• エントリーDOI: 10.2210/pdb8pta/pdb
• 分子名称: Mitogen-activated protein kinase 8, methyl (1R,3S)-1-methyl-3-[[3-[[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]carbamoyl]-4-oxidanylidene-cyclohexane-1-carboxylate, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: mapk kinase, mapk, inhibitor, covalent, jnk, signaling protein, michael acceptor warhead
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 127967.72

構造登録者

Sok, P.,Poti, A.,Remenyi, A. (登録日: 2023-07-13, 公開日: 2024-07-24)

• 主引用文献: Sok, P.,Poti, A.,Balint, D.,Remenyi, A.,Soos, T.; Tunable c-Jun N-terminal kinase (JNK) inhibitors that target a specific cysteine by a reversible covalent bond; To Be Published,

実験手法

X-RAY DIFFRACTION (2.41 Å)