8PST

ERK2 covelently bound to RU60 cyclohexenone based inhibitor

8PST の概要

• エントリーDOI: 10.2210/pdb8pst/pdb
• 分子名称: Mitogen-activated protein kinase 1, AMP PHOSPHORAMIDATE, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{R},3~{S})-1-methyl-4-oxidanylidene-cyclohexane-1,3-dicarboxylate, ... (4 entities in total)
• 機能のキーワード: mapk kinase, mapk, inhibitor, covalent, erk2, michael acceptor warhead, signaling protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42443.48

構造登録者

Sok, P.,Poti, A.,Remenyi, A.,Gogl, G. (登録日: 2023-07-13, 公開日: 2024-07-24)

• 主引用文献: Sok, P.,Poti, A.,Remenyi, A.,Soos, T.,Balint, D.; Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold; To Be Published,

実験手法

X-RAY DIFFRACTION (1.9 Å)