8PRX

Crystal structure of human cathepsin L after reaction with the bound ketoamide inhibitor 13b

8PRX の概要

• エントリーDOI: 10.2210/pdb8prx/pdb
• 関連するPDBエントリー: 8AHV
• 分子名称: Cathepsin L, ~{tert}-butyl ~{N}-[1-[(2~{S})-3-cyclopropyl-1-oxidanylidene-1-[[(2~{S},3~{S})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]amino]propan-2-yl]-2-oxidanylidene-pyridin-3-yl]carbamate, DIMETHYL SULFOXIDE, ... (8 entities in total)
• 機能のキーワード: cystein protease, drug target, lysosome, virus cell entry, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 102003.30

構造登録者

Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (登録日: 2023-07-12, 公開日: 2023-08-23, 最終更新日: 2024-05-22)

• 主引用文献: Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A.; Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.; J.Med.Chem., 67:7048-7067, 2024; PubMed: 38630165; DOI: 10.1021/acs.jmedchem.3c02351

実験手法

X-RAY DIFFRACTION (1.8 Å)