8PQG

c-KIT T670I mutated kinase domain in complex with avapritinib

8PQG の概要

• エントリーDOI: 10.2210/pdb8pqg/pdb
• 分子名称: Mast/stem cell growth factor receptor Kit, Avapritinib (3 entities in total)
• 機能のキーワード: c-kit protein kinase, avapritinib, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, gatekeeper mutant, gatekeeper mutation, p10721, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75410.08

構造登録者

Teuber, A.,Mueller, M.P.,Rauh, D. (登録日: 2023-07-11, 公開日: 2023-12-27, 最終更新日: 2024-08-07)

• 主引用文献: Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D.; Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.; Nat Commun, 15:63-63, 2024; PubMed: 38167404; DOI: 10.1038/s41467-023-44376-8

実験手法