8PQB
c-KIT kinase domain in complex with avapritinib derivative 8
Summary for 8PQB
Entry DOI | 10.2210/pdb8pqb/pdb |
Descriptor | Mast/stem cell growth factor receptor Kit, (1~{S})-1-(4-fluorophenyl)-~{N},~{N}-dimethyl-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine (3 entities in total) |
Functional Keywords | c-kit protein kinase, avapritinib, inhibitor, tyrosine kinase, transmembrane receptor, stem cell factor, scf, stem cell factor receptor, gist, gastrointestinal stromal tumors, p10721, transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 37721.04 |
Authors | Teuber, A.,Niggenaber, J.,Mueller, M.P.,Rauh, D. (deposition date: 2023-07-11, release date: 2023-12-27, Last modification date: 2024-08-07) |
Primary citation | Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D. Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA. Nat Commun, 15:63-63, 2024 Cited by PubMed: 38167404DOI: 10.1038/s41467-023-44376-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.87 Å) |
Structure validation
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