8PP0

Crystal structure of Retinoic Acid Receptor alpha (RXRA) in complexed with JP147

Summary for 8PP0

Entry DOI	10.2210/pdb8pp0/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 3-[4-[2,3-dihydro-1H-inden-4-yl(methyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]oxypropanoic acid, ... (4 entities in total)
Functional Keywords	rxr alpha, inhibitor, structural genomics, structural genomics consortium, sgc, dna binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	29198.70
Authors	Chaikuad, A.,Pollinger, J.,Merk, D.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2023-07-05, release date: 2024-02-07, Last modification date: 2024-02-21)
Primary citation	Lewandowski, M.,Carmina, M.,Knumann, L.,Sai, M.,Willems, S.,Kasch, T.,Pollinger, J.,Knapp, S.,Marschner, J.A.,Chaikuad, A.,Merk, D. Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. J.Med.Chem., 67:2152-2164, 2024 Cited by PubMed: 38237049 DOI: 10.1021/acs.jmedchem.3c02095 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation