8PMO

Crystal structure of human V122I transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder)

8PMO の概要

• エントリーDOI: 10.2210/pdb8pmo/pdb
• 分子名称: Transthyretin, (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone (3 entities in total)
• 機能のキーワード: aggregation, amyloid, t4 hormone binding, protein transport
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28197.24

構造登録者

Varejao, N.,Pinheiro, F.,Pallares, I.,Ventura, S.,Reverter, D. (登録日: 2023-06-29, 公開日: 2024-05-08)

• 主引用文献: Pinheiro, F.,Varejao, N.,Sanchez-Morales, A.,Bezerra, F.,Navarro, S.,Velazquez-Campoy, A.,Busque, F.,Almeida, M.R.,Alibes, R.,Reverter, D.,Pallares, I.,Ventura, S.; PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties.; Eur.J.Med.Chem., 261:115837-115837, 2023; PubMed: 37837673; DOI: 10.1016/j.ejmech.2023.115837

実験手法

X-RAY DIFFRACTION (1.24 Å)