8PKF

ATTRG47E amyloid fibril from hereditary ATTR amloidosis

Summary for 8PKF

• Entry DOI: 10.2210/pdb8pkf/pdb
• EMDB information: 17737
• Descriptor: Transthyretin (1 entity in total)
• Functional Keywords: transthyretin, attr amyloidosis, attrg47e, amyloid fibril, misfolding disease, cryo-em, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 83096.54

Authors

Steinebrei, M.,Schmidt, M.,Faendrich, M. (deposition date: 2023-06-26, release date: 2023-12-06)

Primary citation

Steinebrei, M.,Baur, J.,Pradhan, A.,Kupfer, N.,Wiese, S.,Hegenbart, U.,Schonland, S.O.,Schmidt, M.,Fandrich, M.
Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis.
Nat Commun, 14:7623-7623, 2023

PubMed Abstract: Systemic ATTR amyloidosis is an increasingly important protein misfolding disease that is provoked by the formation of amyloid fibrils from transthyretin protein. The pathological and clinical disease manifestations and the number of pathogenic mutational changes in transthyretin are highly diverse, raising the question whether the different mutations may lead to different fibril morphologies. Using cryo-electron microscopy, however, we show here that the fibril structure is remarkably similar in patients that are affected by different mutations. Our data suggest that the circumstances under which these fibrils are formed and deposited inside the body - and not only the fibril morphology - are crucial for defining the phenotypic variability in many patients.

PubMed: 37993462
DOI: 10.1038/s41467-023-43301-3

Experimental method

ELECTRON MICROSCOPY (2.3673 Å)