8PJ0

Pseudomonas aeruginosa FabF C164A mutant in complex with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbutanamide

Summary for 8PJ0

Entry DOI	10.2210/pdb8pj0/pdb
Descriptor	3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... (5 entities in total)
Functional Keywords	inhibitor, protein-ligand complex, fabf, transferase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	4
Total formula weight	177741.99
Authors	Georgiou, C.,Brenk, R.,Espeland, L.O. (deposition date: 2023-06-22, release date: 2024-02-21, Last modification date: 2024-05-08)
Primary citation	Jalencas, X.,Berg, H.,Espeland, L.O.,Sreeramulu, S.,Kinnen, F.,Richter, C.,Georgiou, C.,Yadrykhinsky, V.,Specker, E.,Jaudzems, K.,Miletic, T.,Harmel, R.,Gribbon, P.,Schwalbe, H.,Brenk, R.,Jirgensons, A.,Zaliani, A.,Mestres, J. Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection. Rsc Med Chem, 15:1176-1188, 2024 Cited by PubMed: 38665834 DOI: 10.1039/d3md00724c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation