8PI9
DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A)
Summary for 8PI9
Entry DOI | 10.2210/pdb8pi9/pdb |
Descriptor | Chains: E, Chains: F, Hepatocyte nuclear factor 1-alpha (3 entities in total) |
Functional Keywords | transcription factor, dna binding protein, gene transcription, hnf-1a, hnf4a, mody |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 58634.90 |
Authors | Kind, L.,Myllykoski, M.,Raasakka, A.,Kursula, P. (deposition date: 2023-06-21, release date: 2024-06-19) |
Primary citation | Kind, L.,Molnes, J.,Tjora, E.,Raasakka, A.,Myllykoski, M.,Colclough, K.,Saint-Martin, C.,Adelfalk, C.,Dusatkova, P.,Pruhova, S.,Valtonen-Andre, C.,Bellanne-Chantelot, C.,Arnesen, T.,Kursula, P.,Njolstad, P.R. Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes. JCI Insight, 9:-, 2024 Cited by PubMed: 38855865DOI: 10.1172/jci.insight.175278 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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