8PI9

DNA binding domain of HNF-1A bound to P2-HNF4A promoter DNA variant (P2 -181G>A)

8PI9 の概要

• エントリーDOI: 10.2210/pdb8pi9/pdb
• 分子名称: Chains: E, Chains: F, Hepatocyte nuclear factor 1-alpha (3 entities in total)
• 機能のキーワード: transcription factor, dna binding protein, gene transcription, hnf-1a, hnf4a, mody
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58634.90

構造登録者

Kind, L.,Myllykoski, M.,Raasakka, A.,Kursula, P. (登録日: 2023-06-21, 公開日: 2024-06-19)

• 主引用文献: Kind, L.,Molnes, J.,Tjora, E.,Raasakka, A.,Myllykoski, M.,Colclough, K.,Saint-Martin, C.,Adelfalk, C.,Dusatkova, P.,Pruhova, S.,Valtonen-Andre, C.,Bellanne-Chantelot, C.,Arnesen, T.,Kursula, P.,Njolstad, P.R.; Molecular mechanism of HNF-1A-mediated HNF4A gene regulation and promoter-driven HNF4A-MODY diabetes.; JCI Insight, 9:-, 2024; PubMed: 38855865; DOI: 10.1172/jci.insight.175278

実験手法

X-RAY DIFFRACTION (2.8 Å)