8PF2

Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK16

Summary for 8PF2

• Entry DOI: 10.2210/pdb8pf2/pdb
• Descriptor: Chemotaxis protein CheA, RESORCINOL (3 entities in total)
• Functional Keywords: inhibitor, transferase, signaling protein
• Biological source: Thermotoga maritima
• Total number of polymer chains: 2
• Total formula weight: 42378.76

Authors

Adhav, A.,Marina, A. (deposition date: 2023-06-15, release date: 2024-06-26, Last modification date: 2024-07-10)

• Primary citation: Fernandez-Ciruelos, B.,Albanese, M.,Adhav, A.,Solomin, V.,Ritchie-Martinez, A.,Taverne, F.,Velikova, N.,Jirgensons, A.,Marina, A.,Finn, P.W.,Wells, J.M.; Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity.; Microbiol Spectr, :e0014624-e0014624, 2024; PubMed: 38917423; DOI: 10.1128/spectrum.00146-24

Experimental method

X-RAY DIFFRACTION (2.1 Å)