8PF2

Structure of the Histidine Kinase CheA ATP-Binding domain in complex with compound ODDHK16

8PF2 の概要

• エントリーDOI: 10.2210/pdb8pf2/pdb
• 分子名称: Chemotaxis protein CheA, RESORCINOL (3 entities in total)
• 機能のキーワード: inhibitor, transferase, signaling protein
• 由来する生物種: Thermotoga maritima
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 42378.76

構造登録者

Adhav, A.,Marina, A. (登録日: 2023-06-15, 公開日: 2024-06-26, 最終更新日: 2024-08-21)

• 主引用文献: Fernandez-Ciruelos, B.,Albanese, M.,Adhav, A.,Solomin, V.,Ritchie-Martinez, A.,Taverne, F.,Velikova, N.,Jirgensons, A.,Marina, A.,Finn, P.W.,Wells, J.M.; Repurposing Hsp90 inhibitors as antimicrobials targeting two-component systems identifies compounds leading to loss of bacterial membrane integrity.; Microbiol Spectr, 12:e0014624-e0014624, 2024; PubMed: 38917423; DOI: 10.1128/spectrum.00146-24

実験手法

X-RAY DIFFRACTION (2.1 Å)