8PEC
OXA-48_Q5-CAZ. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution
Summary for 8PEC
Entry DOI | 10.2210/pdb8pec/pdb |
Descriptor | Beta-lactamase, 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | protein evolution. antibiotic resistance. oxa-48. hydrolase. serine-beta-lactamase., hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 4 |
Total formula weight | 113730.56 |
Authors | |
Primary citation | Frohlich, C.,Leiros, H.-K.S. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution. To Be Published, 2024 Cited by DOI: 10.1038/s41929-024-01117-4PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.66 Å) |
Structure validation
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