8PEC

OXA-48_Q5-CAZ. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution

8PEC の概要

• エントリーDOI: 10.2210/pdb8pec/pdb
• 分子名称: Beta-lactamase, 1-({(2R)-2-[(1R)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-2-oxoethyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: protein evolution. antibiotic resistance. oxa-48. hydrolase. serine-beta-lactamase., hydrolase
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 113730.56

構造登録者

Leiros, H.-K.S.,Frohlich, C. (登録日: 2023-06-13, 公開日: 2024-02-14, 最終更新日: 2024-06-12)

• 主引用文献: Frohlich, C.,Bunzel, H.A.,Buda, K.,Mulholland, A.J.,van der Kamp, M.W.,Johnsen, P.J.,Leiros, H.S.,Tokuriki, N.; Epistasis arises from shifting the rate-limiting step during enzyme evolution of a beta-lactamase.; Nat Catal, 7:499-509, 2024; PubMed: 38828429; DOI: 10.1038/s41929-024-01117-4

実験手法

X-RAY DIFFRACTION (2.66 Å)