8PE1

Crystal structure of Gel4 in complex with Nanobody 4

Summary for 8PE1

• Entry DOI: 10.2210/pdb8pe1/pdb
• Descriptor: 1,3-beta-glucanosyltransferase, Nanobody 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: transglycosylase, b-1, 3-glucan, nanobodies, fungal diseases, transferase
• Biological source: Aspergillus fumigatus Af293; More
• Total number of polymer chains: 4
• Total formula weight: 131934.49

Authors

Macias-Leon, J.,Redrado-Hernandez, S.,Castro-Lopez, J.,Sanz, A.B.,Arias, M.,Farkas, V.,Vincke, C.,Muyldermans, S.,Pardo, J.,Arroyo, J.,Galvez, E.,Hurtado-Guerrero, R. (deposition date: 2023-06-13, release date: 2024-06-19, Last modification date: 2024-07-31)

• Primary citation: Redrado-Hernandez, S.,Macias-Leon, J.,Castro-Lopez, J.,Belen Sanz, A.,Dolader, E.,Arias, M.,Gonzalez-Ramirez, A.M.,Sanchez-Navarro, D.,Petryk, Y.,Farkas, V.,Vincke, C.,Muyldermans, S.,Garcia-Barbazan, I.,Del Agua, C.,Zaragoza, O.,Arroyo, J.,Pardo, J.,Galvez, E.M.,Hurtado-Guerrero, R.; Broad Protection against Invasive Fungal Disease from a Nanobody Targeting the Active Site of Fungal beta-1,3-Glucanosyltransferases.; Angew.Chem.Int.Ed.Engl., :e202405823-e202405823, 2024; PubMed: 38856634; DOI: 10.1002/anie.202405823

Experimental method