8PE1

Crystal structure of Gel4 in complex with Nanobody 4

8PE1 の概要

• エントリーDOI: 10.2210/pdb8pe1/pdb
• 分子名称: 1,3-beta-glucanosyltransferase, Nanobody 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: transglycosylase, b-1, 3-glucan, nanobodies, fungal diseases, transferase
• 由来する生物種: Aspergillus fumigatus Af293; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 131934.49

構造登録者

Macias-Leon, J.,Redrado-Hernandez, S.,Castro-Lopez, J.,Sanz, A.B.,Arias, M.,Farkas, V.,Vincke, C.,Muyldermans, S.,Pardo, J.,Arroyo, J.,Galvez, E.,Hurtado-Guerrero, R. (登録日: 2023-06-13, 公開日: 2024-06-19, 最終更新日: 2024-06-26)

• 主引用文献: Redrado-Hernandez, S.,Macias-Leon, J.,Castro-Lopez, J.,Sanz, A.B.,Dolader, E.,Arias, M.,Gonzalez-Ramirez, A.M.,Sanchez-Navarro, D.,Petryk, Y.,Farkas, V.,Vincke, C.,Muyldermans, S.,Garcia-Barbazan, I.,Del Agua, C.,Zaragoza, O.,Arroyo, J.,Pardo, J.,Galvez, E.,Hurtado-Guerrero, R.; Broad protection against invasive fungal disease from a nanobody targeting the active site of fungal b-1,3-glucanosyltransferases.; Angew.Chem.Int.Ed.Engl., :e202405823-e202405823, 2024; PubMed: 38856634; DOI: 10.1002/anie.202405823

実験手法

X-RAY DIFFRACTION (1.9 Å)